Les publications
COVID-19
Diedisheim M, Dancoisne E, Gautier JF, Larger E, Cosson E, Fève B, Chanson P, Czernichow S, Tatulashvili S, Raffin-Sanson ML, Bourgeon M, Ajzenberg C, Hartemann A, Daniel C, Moreau T, Roussel R, Potier L. Diabetes increases severe COVID-19 outcomes primarily in younger adults Age and diabetes in COVID-19 severity. J Clin Endocrinol Metab. 2021 Jun 1:dgab393. doi: 10.1210/clinem/dgab393. Epub ahead of print. PMID: 34060606; PMCID: PMC8195170.
Hoertel N, Sánchez-Rico M, Vernet R, Beeker N, Neuraz A, Alvarado JM, et al. Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study. Br J Clin Pharmacol. 2021 Feb 11. PMID: 33608891.
Chouchana L, Beeker N, Garcelon N, Rance B, Paris N, Salamanca E, et al. Association of Antihypertensive Agents with the Risk of In-Hospital Death in Patients with Covid-19. Cardiovasc Drugs Ther. 2021 Jun 01. doi: 10.1007/s10557-021-07155-5. PMID: 33595761.
Hoertel N, Sánchez-Rico M, Vernet R, Jannot A-S, Neuraz A, Blanco C, et al. Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19. Clin Drug Investig. 2021 Dec 16. doi: 10.1007/s40261-021-01001-0. PMID: 33559821.
Hoertel N, Sánchez-Rico M, Vernet R, Beeker N, Jannot A-S, Neuraz A, et al. Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study. Mol Psychiatry. 2021 Feb 04. PMID: 33536545.
Kohane IS, Aronow BJ, Avillach P, Beaulieu-Jones BK, Bellazzi R, Bradford RL, et al. What Every Reader Should Know About Studies Using Electronic Health Record Data but May be Afraid to Ask. J Med Internet Res. 2021 Mar 02. PMID: 33600347.
Hoertel N, Sánchez-Rico M, Vernet R, Jannot A-S, Neuraz A, Blanco C, et al. Observational study of haloperidol in hospitalized patients with COVID-19. PLoS One. 2021 Feb 22;16(2):e0247122. PMID: 33606790.
Czernichow S, Beeker N, Rives-Lange C, Guerot E, Diehl J-L, Katsahian S, et al. Obesity Doubles Mortality in Patients Hospitalized for Severe Acute Respiratory Syndrome Coronavirus 2 in Paris Hospitals, France: A Cohort Study on 5,795 Patients. Obesity (Silver Spring). déc 2020;28(12):2282-9. PMID: 32815621.
Bataille P, Amiot A, Claudepierre P, Paris N, Neuraz A, Lerner I, et al. Letter: severe COVID-19 infection and biologic therapies-a cohort study of 7 808 patients in France. Aliment Pharmacol Ther. 2020 Oct ;52(7):1245 8. doi: 10.1111/apt.16040.
Neuraz A, Lerner I, Digan W, Paris N, Tsopra R, Rogier A, et al. Natural Language Processing for Rapid Response to Emergent Diseases: Case Study of Calcium Channel Blockers and Hypertension in the COVID-19 Pandemic. J Med Internet Res. 2020 Aug 14;22(8):e20773. PMID: 32759101.
Daniel C. La recherche clinique à partir d’entrepôts de données. L’expérience de l’Assistance Publique – Hôpitaux de Paris (AP–HP) à l’épreuve de la pandémie de Covid-19. Rev Med Interne. 2020 Apr 05;41(5):303-307. French. doi:10.1016/j.revmed.2020.04.005.
Brat GA, Weber GM, Gehlenborg N, Avillach P, Palmer NP, Chiovato L, et al. International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ Digit Med. 2020 Aug 19;3:109. PMID: 32864472.
Hennocq Q, Adjed C, Chappuy H, Orliaguet G, Monteil C, Kebir CE, Picard A, Segna E, Beeker N, Khonsari RH. Injuries and child abuse increase during the pandemic over 12942 emergency admissions. Injury. 2022 Aug 13. doi 10.1016/j.injury.2022.08.013. PMID: 36008172.
Dr Anna Molto. Evaluation of the prevalence of new-onset musculoskeletal symptoms in patients hospitalized for severe SARS-CoV2 infection during the first two COVID waves in France: a descriptive analysis of the clinical data warehouse of 39 hospitals in France. 2022 Aug 06. doi 10.1016/j.jbspin.2022.105450. Online ahead of print. PMID: 36008172.
Clémence Marois, Thomas Nedelec, Juliette Pelle, Antoine Rozes, Stanley Durrleman, Carole Dufouil, Alexandre Demoule. Comparison of Clinical Profiles and Mortality Outcomes Between Influenza and COVID-19 Patients Invasively Ventilated in the ICU: A Retrospective Study From All Paris Public Hospitals From 2016 to 2021. Critical care explorations. 2022 Jul 25. doi 10.1097/CCE.0000000000000737. PMID: 35923591.
Urbina T, Lavillegrand JR, Garnier M, Mekinian A, Pacanowski J, Mario N, Dumas G, Hariri G, Pilon A, Darrivère L, Fartoukh M, Guidet B, Maury E, Leblanc J, Chantran Y, Fain O, Lacombe K, Voiriot G, et al. Delayed inflammation decrease is associated with mortality in Tocilizumab-treated critically ill SARS-CoV-2 patients: A retrospective matched-cohort analysis. Innate Immun. 2022 Jan 31. doi 10.1177/17534259211064602. PMID: 35089113.
Revel MP, Beeker N, Porcher R, Jilet L, Fournier L, Rance B, Chassagnon G, Fontenay M, Sanchez O; AP-HP /Universities/Inserm COVID-19 research collaboration, AP-HP Covid CDR Initiative. What level of D-dimers can safely exclude pulmonary embolism in COVID-19 patients presenting to the emergency department? European Radiology. 2022 Jan 07. doi 10.1007/s00330-021-08377-9. PMID: 34994845.
Sánchez-Rico, M ; Limosin, F ; Vernet, R ; Beeker, N ; Neuraz, A ; Blanco, C et al. Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study. J Clin Med. 2021 Dec 15. doi 10.3390/jcm10245891. PMID: 34945186.
Hoertel, N ; Sánchez-Rico, M ; Gulbins, E ; Kornhuber, J ; Carpinteiro, A ; Lenze, EJ et al. Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study. Clin Pharmacol Ther. 2021 Dec 01. doi 10.1002/cpt.2317. PMID: 34050932.
Hoertel N, Sánchez-Rico M, Herrera-Morueco JJ, de la Muela P, Gulbins E, Kornhuber J, Carpinteiro A, Becker KA, Cougoule C, Limosin F. Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality: Results from 49,089 COVID-19 inpatients. Molecular Psychiatry. 2021 Nov 26. doi 10.1038/s41380-021-01393-7. PMID: 34837060.
Diedisheim, M ; Dancoisne, E ; Gautier, JF ; Larger, E ; Cosson, E ; Fève, B et al. Response to Letter to the Editor From Woolcott and Castilla-Bancayán: "Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults". J Clin Endocrinol Metab. 2021 Nov 19. PMID: 34370033.
Benderra, MA ; Aparicio, A ; Leblanc, J ; Wassermann, D ; Kempf, E ; Galula, G et al. Clinical Characteristics, Care Trajectories and Mortality Rate of SARS-CoV-2 Infected Cancer Patients: A Multicenter Cohort Study. Cancers (Basel). 2021 Oct 15. PMID: 34638235.
Le TT, Gutiérrez-Sacristán A, Son J, Hong C, South AM, Beaulieu-Jones BK, Loh NHW, Luo Y, Morris M, Ngiam KY, Patel LP, Samayamuthu MJ, Schriver E, Tan ALM, Moore J, Cai T, Omenn GS, Avillach P, et al. Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19. 2021 Oct 11. doi 10.1038/s41598-021-99481-9. PMID: 34642371.
Weber, GM ; Zhang, HG ; L'Yi, S ; Bonzel, CL ; Hong, C ; Avillach, P et al. International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study. J Med Internet Res. 2021 Oct 11. PMID: 34533459.
Lombardi, Y ; Azoyan, L ; Szychowiak, P ; Bellamine, A ; Lemaitre, G ; Bernaux, M et al. External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals. Intensive Care Med. 2021 Sep 28. PMID: 34585270.
Estiri H, Strasser ZH, Brat GA, Semenov YR, Patel CJ, Murphy SN, AP-HP COVID CDR Initiative. Evolving phenotypes of non-hospitalized patients that indicate long COVID. 2021 Sep 27. doi : 10.1186/s12916-021-02115-0. PMID : 34565368.
Bourgeois, FT ; Gutiérrez-Sacristán, A ; Keller, MS ; Liu, M ; Hong, C ; Bonzel, CL et al. International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries. JAMA Netw Open. 2021 Jun 11. PMID: 34115127.
Diedisheim, M ; Dancoisne, E ; Gautier, JF ; Larger, E ; Cosson, E ; Fève, B et al. Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults. J Clin Endocrinol Metab. 2021 Jun 02. PMID : 34406396.
Kempf, E ; Lamé, G ; Layese, R ; Priou, S ; Chatellier, G ; Chaieb, H et al. New cancer cases at the time of SARS-Cov2 pandemic and related public health policies: A persistent and concerning decrease long after the end of the national lockdown. Eur J Cancer. 2021 Jun 01. PMID : 33940350.
Mustafic, H ; Fayssoil, A ; Josseran, L ; Ouadahi, M ; Grimaldi-Bensouda, L ; Dubourg, O et al. Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers in Hypertensive Patients with COVID-19 (COVIDECA Study). Am J Cardiol. 2021 May 15. PMID : 33617818.
Pierre Deltenre, Christophe Moreno, Eric Trépo. Progressive cholangiopathy in COVID-19 patients: Other possible diagnoses than ketamine-induced cholangiopathy should be considered. J Hepatol. 2021 Mar 19. doi : 10.1016/j.jhep.2021.02.036.
Jannot, AS ; Countouris, H ; Van Straaten, A ; Burgun, A ; Katsahian, S ; Rance, B. Low-income neighbourhood was a key determinant of severe COVID-19 incidence during the first wave of the epidemic in Paris. J Epidemiol Community Health. 2020 Jun 21. PMID: 34193571
Coscas R, Dubosq M, Charton J, El Batti S, Gaudric J, Koskas F, Chiche L, Couture T, Davaine JM, Castier Y, Cerceau P, El Hajjam M, Samb P, Beauchet A, Grimaldi L, Javerliat I, Goeau-Brissonniere O, Alsac JM, Onorati I, Martinod E, Desgranges P, Touma J, Cochennec F, Pellenc Q, Julia P, Coggia M. Thrombosis of Medium-Sized and Large Arteries During Covid-19 Infection: Results of the COVIVASC Study. Ann Vasc Surg. 2022 Oct;86:35-42. doi: 10.1016/j.avsg.2022.04.055. Epub 2022 Jun 30. PMID: 35780947; PMCID: PMC9242891
Daniel C, Paris N, Pierre O, Griffon N, Breant S, Orlova N, Serre P, Leprovost D, Denglos S, Mouchet A, Dubiel J, Gozlan R, Chatellier G, Bey R, Frank M, Hassen-Khodja C, Mamzer MF, Hilka M; AP-HP Covid CDW Initiative. AP-HP Health Data Space (AHDS) to the Test of the Covid-19 Pandemic. Stud Health Technol Inform. 2022 May 25;294:28-32. doi: 10.3233/SHTI220390. PMID: 35612010.
Aparicio T, Layese R, Hemery F, Tournigand C, Paillaud E, De Angelis N, Quero L, Ganne N, Prat F, Pachev A, Galula G, Benderra MA, Canouï-Poitrine F; Clinical Data Warehouse of Greater Paris University Hospitals/INSERM COVID-19 research collaboration and the Cancer AP-HP Group. The 10-month mortality rate among older patients treated for digestive system cancer during the first wave of the COVID-19 pandemic: The CADIGCOVAGE multicentre cohort study. J Geriatr Oncol. 2023 Mar;14(2):101443. doi: 10.1016/j.jgo.2023.101443. Epub 2023 Jan 27. PMID: 36709553; PMCID: PMC9883010.
Khonsari RH, Bernaux M, Vie JJ, Diallo A, Paris N, Luong LB, Assouad J, Paugam C, Simon T, Vicaut E, Nizard R, Vibert E; AP-HP/Universities/INSERM COVID-19 research collaboration, AP-HP COVID Clinical Data Warehouse initiative. Risks of early mortality and pulmonary complications following surgery in patients with COVID-19. Br J Surg. 2021 Apr 30;108(4):e158-e159. doi: 10.1093/bjs/znab007. PMID: 33793755; PMCID: PMC7929121.
Semeraro M, Pinson P, Populaire M, Dellagi M, Oualha M, Beeker N, Chappuy H. Analysis of the impact of the SARS-CoV-2 infection on the pediatric population hospitalized during the pandemic in the Greater Paris University Hospitals. Front Pediatr. 2023 Feb 27;11:1044352. doi: 10.3389/fped.2023.1044352. PMID: 36923274; PMCID: PMC10009109.
Chevalier K, Genin M, Jean TP, Avouac J, Flipo RM, Georgin-Lavialle S, El Mahou S, Pertuiset E, Pham T, Servettaz A, Marotte H, Domont F, Chazerain P, Devaux M, Mekinian A, Sellam J, Fautrel B, Rouzaud D, Ebstein E, Costedoat-Chalumeau N, Richez C, Hachulla E, Mariette X, Seror R. CovAID: Identification of factors associated with severe COVID-19 in patients with inflammatory rheumatism or autoimmune diseases. Front Med (Lausanne). 2023 Mar 22;10:1152587. doi: 10.3389/fmed.2023.1152587. PMID: 37035330; PMCID: PMC10075312.
Dupont, A., Couffignal, C., Arias, C. et al. Outcomes and risk factors with COVID-19 or influenza in hospitalized asthma patients. Respir Res 23, 342 (2022). https://doi.org/10.1186/s12931-022-02265-6
Recherche clinique et innovation
Rech J-S, Yao K, Bachmeyer C, Bailleul S, Javier O, Grateau G, et al. Prognostic Value of Hyponatremia During Acute Painful Episodes in Sickle Cell Disease. Am J Med. sept 2020;133(9):e465-82.
Fayand A, Dzierzynski N, Georgin-Lavialle S, Bachmeyer C, Mattioni S, Stankovic-Stojanovic K, Lionnet F, Steichen O. The association of psychiatric comorbidities with emergency visits and hospitalisations in adult sickle-cell patients: a cohort study. Br J Haematol. 2020 Feb 18. doi: 10.1111/bjh.16417. PMID: 32072613.
Lampros, A ; Montardi, C ; Journeau, L ; Georgin-Lavialle, S ; Hanslik, T ; Dhôte, R et al. Association between psychiatric comorbidities and hospital length of stay in post-emergency internal medicine patients. Rev Med Interne. 2020 Jan 22. pii: S0248-8663(20)30004-7. doi: 10.1016/j.revmed.2019.12.016. [Epub ahead of print] French. PubMed PMID: 31982256.
Lerner I, Paris N, Tannier X. Terminologies augmented recurrent neural network model for clinical named entity recognition. J Biomed Inform. 2019 Dec 16;102:103356. doi: 10.1016/j.jbi.2019.103356. PMID: 31837473.
Simona Bottani, Ninon Burgos, Aurlien Maire, Adam Wild, Sebastian Strer, Didier Dormont, Olivier Colliot. Automatic quality control of brain T1-weighted magnetic resonance images for a clinical data warehouse. Medical Image Analysis. 102219, ISSN 1361-8415, https://doi.org/10.1016/j.media.2021.102219
Chaigne B, Tieu A, Beeker N, Zuelgaray E, Bouaziz JD, Sène D, Dupin N, Mouthon L. Cluster analysis reveals eosinophilia and fibrosis as poor prognostic markers in 128 patients with eosinophilic fasciitis. J Am Acad Dermatol. 2022 Aug 19. doi: 10.1016/j.jaad.2022.08.026. PMID: 35995088
Abbara S, Guillemot D, El Oualydy S, Kos M, Poret C, Breant S, Brun-Buisson C, Watier L. Antimicrobial Resistance and Mortality in Hospitalized Patients with Bacteremia in the Greater Paris Area from 2016 to 2019. Clin Epidemiol. 2022 Dec 14;14:1547-1560. doi: 10.2147/CLEP.S385555. PMID: 36540898.
Pauline Bataille, Richard Layese, Pascal Claudepierre, Nicolas Paris, Julien Dubiel, Aurélien Amiot, Emilie Sbidian. Paradoxical reactions and biologic agents: a French cohort study of 9,303 patients. Br J Dermatol. 2022 Jun 30. doi: 10.1111/bjd.21716. PMID: 35770735
Roux, C ; Rozes, A ; Reizine, D ; Hajage, D ; Daniel, C ; Maire, A et al. Fully automated opportunistic screening of vertebral fractures and osteoporosis on more than 150,000 routine computed tomography scans. Rheumatology (Oxford). 2022 Aug 03. doi: 10.1093/rheumatology/keab878. PMID: 34850864.
D. Naouri, N. Pelletier-Fleury, N. Lapidus et Y. Yordanov. The effect of direct admission to acute geriatric units compared to admission after an emergency department visit on length of stay, postacute care transfers and ED return visits. 2022 Jul 04. doi: 10.1186/s12877-022-03241-x. PMID: 35788184.
Fartoukh, M ; Voiriot, G ; Guérin, L ; Ricard, JD ; Combes, A ; Faure, M et al. Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study. Ann Intensive Care. 2021 Jul 29. PMID: 34324076
Camille Windsor , Camille Hua, Quentin De Roux, Anatole Harrois, Nadia Anguel, Philippe Montravers, Antoine Vieillard‑Baron, Jean‑Paul Mira, Tomas Urbina, Stéphane Gaudry, Matthieu Turpin,Charles Damoisel, Djillali Annane, Jean‑Damien Ricard, Barbara Hersant, Armand Mekontso Dessap, Olivier Chosidow, Richard Layese, Nicolas de Prost* and AP‑HP NSTI study group. Healthcare trajectory of critically ill patients with necrotizing soft tissue infections: a multicenter retrospective cohort study using the clinical data warehouse of Greater Paris University Hospitals. Annals of Intensive Care. 2022 Dec 20. doi: 10.1186/s13613-022-01087-5. PMID: 36538244.
Celante H, Oubaya N, Fourati S, Beaune S, Khellaf M, Casalino E, Ricard JD, Vieillard-Baron A, Heming N, Mekontso Dessap A, de Montmollin E, Benghanem S, Epaillard N, Layese R, de Prost N; Prono-RSV study group of the clinical data warehouse of Greater Paris University Hospitals. Prognosis of hospitalised adult patients with respiratory syncytial virus infection: a multicentre retrospective cohort study. Clin Microbiol Infect. 2023 Mar 11:S1198-743X(23)00117-9. doi: 10.1016/j.cmi.2023.03.003. Epub ahead of print. PMID: 36914069.
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Recherche technologique
Daniel C, Serre P, Orlova N, Bréant S, Paris N, Griffon N. Initializing a hospital-wide data quality program. The AP-HP experience. Comput Methods Programs Biomed. 2019 Nov;181:104804. doi: 10.1016/j.cmpb.2018.10.016. PMID: 30497872.
Thomassin-Naggara, I ; Balleyguier, C ; Ceugnart, L ; Heid, P ; Lenczner, G ; Maire, A et al. Artificial intelligence and breast screening: French Radiology Community position paper. Diagn Interv Imaging. 2019 Oct;100(10):553-566. doi: 10.1016/j.diii.2019.08.005. Epub 2019 Sep 12. PubMed PMID: 31523026.
Paris N, Mendis M, Daniel C, Murphy S, Tannier X, Zweigenbaum P. i2b2 implemented over SMART-on-FHIR. AMIA Jt Summits Transl Sci Proc. 2018 May 18;2017:369-378. eCollection 2018. PubMed PMID: 29888095; PubMed Central PMCID: PMC5961782.
Montagne, S., Hamzaoui, D., Allera, A. et al. Challenge of prostate MRI segmentation on T2-weighted images: inter-observer variability and impact of prostate morphology. Insights Imaging 12, 71 (2021). https://doi.org/10.1186/s13244-021-01010-9
S. Karunakaran, D. Van Gysel, S. Guinemer, I. Mahe, K. Sallah. Reconstruction de variables structurées à partir des données textuelles d’un entrepôt de données de santé, à des fins de recherche clinique, Paris. Revue d'Épidémiologie et de Santé Publique. 2020 Feb 28.
Gérardin C, Wajsbürt P, Vaillant P, Bellamine A, Carrat F, Tannier X. Multilabel classification of medical concepts for patient clinical profile identification. Artif Intell Med. 2022 Jun. doi: 10.1016/j.artmed.2022.102311. PMID: 35534148.
Dimitri Hamzaoui, Sarah Montagne, Benjamin Granger, Alexandre Allera, Malek Ezziane, Anna Luzurier, Raphaëlle Quint, Mehdi Kalai, Nicholas Ayache, Hervé Delingette, Raphaële Renard Penna. Prostate volume prediction on MRI: tools, accuracy and variability. European Radiology. 2022 Jul. doi: 10.1007/s00330-022-08554-4. PMID: 35169895.
Perceval Wajsbürt, Arnaud Sarfati, Xavier Tannier. Medical concept normalization in French using multilingual terminologies and contextual embeddings. Journal of Biomedical Informatics. Vol. 12, Issue 114, 2021 Feb. doi: 10.1016/j.jbi.2021.103684
Gault, N ; Sallah, K ; Régent, A ; Le Jeunne, C ; Lechat, P. Analysis of off-label prescriptions of medicines in hospital in adult patients and feasibility study of their detection using CIM-10 coding. Therapie. 2022 Jun. doi: 10.1016/j.therap.2021.10.005. PMID: 35012758.
Lerner, Ivan, Jordan Jouffroy, Anita Burgun, et Antoine Neuraz. Learning the grammar of prescription: recurrent neural network grammars for medication information extraction in clinical texts. arXiv. 2022 Apr 05.
Jouffroy, J ; Feldman, SF ; Lerner, I ; Rance, B ; Burgun, A ; Neuraz, A. Hybrid Deep Learning for Medication-Related Information Extraction From Clinical Texts in French: MedExt Algorithm Development Study. JMIR Med Inform. 2021 Mar 16. PMID: 33724196.
K. Sallah, N. Gault, D. Van Gysel, G. Luquiens, P. Lechat. Élaboration d’un référentiel mettant en lien des champs textuels d’indications thérapeutiques avec des libellés diagnostiques, en vue de la détection de prescriptions hors AMM dans les dossiers médicaux. Revue d'Épidémiologie et de Santé Publique. 2019 May.
Bannour N, Wajsbürt P, Rance B, Tannier X, Névéol A. Privacy-preserving mimic models for clinical named entity recognition in French. J Biomed Inform. 2022 Jun;130:104073. doi: 10.1016/j.jbi.2022.104073. Epub 2022 Apr 12. PMID: 35427797.
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